Macitentan Improves Risk Categorization for Liver Transplant Mortality in Patients With Portopulmonary Hypertension: A PORTICO Study Post Hoc Analysis
نویسندگان
چکیده
منابع مشابه
Portopulmonary hypertension and the liver transplant candidate.
The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention t...
متن کاملGenetic risk factors for portopulmonary hypertension in patients with advanced liver disease.
RATIONALE Portopulmonary hypertension (PPHTN) occurs in 6% of liver transplant candidates. The pathogenesis of this complication of portal hypertension is poorly understood. OBJECTIVES To identify genetic risk factors for PPHTN in patients with advanced liver disease. METHODS We performed a multicenter case-control study of patients with portal hypertension. Cases had a mean pulmonary arter...
متن کاملPreoperative Assessment and Management of Liver Transplant Candidates With Portopulmonary Hypertension
Michael J. Krowka, MD Professor of Medicine Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester, MN Pulmonary artery hypertension (PAH) that occurs as a consequence of portal hypertension is termed portopulmonary hypertension (POPH) and is associated with significant morbidity and mortality. Among liver transplant (LT) candidates, reported incidence rates of POPH range from 4...
متن کاملAmbrisentan improves exercise capacity and symptoms in patients with portopulmonary hypertension.
INTRODUCTION Ambrisentan, a selective endothelin receptor antagonist has been approved in several countries for pulmonary arterial hypertension. No data have been published on the efficacy of ambrisentan on improvement of exercise capacity in patients with portopulmonary hypertension (PoPH). PATIENTS AND METHODS We retrospectively analyzed the safety and efficacy of ambrisentan in patients wi...
متن کاملInternational Liver Transplant Society Practice Guidelines: Diagnosis and Management of Hepatopulmonary Syndrome and Portopulmonary Hypertension.
Two distinct pulmonary vascular disorders, hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) may occur as a consequence of hepatic parenchymal or vascular abnormalities. HPS and POPH have major clinical implications for liver transplantation. A European Respiratory Society Task Force on Pulmonary-Hepatic Disorders convened in 2002 to standardize the diagnosis and guide manag...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2020
ISSN: 1527-6465,1527-6473
DOI: 10.1002/lt.25747